Instead, I seek to know why T regulatory cells that are induced by high levels of TGF beta-1 can change in tissue affected by high IL-6 and IL-17 to become pathogenic T cells, ones that add to the burden of humoral inflammatory mediators. I get to see the very worst chronic fatiguers regain health when they have their non-existent vasoactive intestinal polypeptide (VIP) replenished. And I get to write the IRB applications that let me do such work. Some days, I feel invigorated by such excitement, but face it, there are the days when people aren’t getting better and the defense counsel in the big case in Georgia just produced an affidavit from a guy who has never treated anyone with illness from a water-damaged building that attacks me viciously. Those days are fewer now that the research group I work with has published a lot of good studies, yet they will occur predictably in the future. If one wants to avoid being bitten by snakes, a good idea is to not step into snake pits.
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